Figure 1: Synthetic strategies to access secondary and tertiary alcohols by carbonyl addition reactions. Despite considerable advances, and the abundance of organometallic reagents developed for ...

We decided to evaluate the use of alkenes as alkylmetal equivalents in catalytic asymmetric conjugate addition (ACA). These reactions would be strategically important because they would accomplish ...

Although nature provides us with a supply of substances that we have adapted for a number of uses, the importance of being able to create ‘designer’ molecules should not be underestimated. Since the ...

Synthetic chemists prize organolithium reagents for their ability to build carbon-carbon bonds. But their extreme reactivity also makes them dangerous—they can spontaneously ignite when exposed to air ...

Highly reactive organometallic reagents, like organolithiums (molecules with a carbon–lithium bond) are essential reagents in organic synthesis because of their applications from polymer synthesis to ...

Organolithium and magnesium reagents are staples in chemical stockrooms. Useful in an array of reactions, they may experience their heaviest demand from cross-coupling reactions. In two such reactions ...

A recent academic paper published in the journal Organic Process Research and Development by the Group of Prof Steven V. Ley, Department of Chemistry, University of Cambridge outlines a breakthrough ...